Posts by Adam Tyson
An atlas for the prairie vole Microtus ochrogaster has been added to BrainGlobe
- 30 October 2024
Prairie voles are a valuable model species for studying social interaction due to their characteristic pair-bonding behavior. The brain of this species is structured similarly to the mouse and is only 30% larger, meaning it is particularly well suited to methods to map brain anatomy and function using light microscopy, such as light-sheet fluorescence microscopy and serial section two-photon microscopy.
A mouse brain atlas with barrel field annotations has been added to BrainGlobe
- 02 August 2024
Bolaños-Puchet et al., 2024 recently published annotations of 33 barrels and barrel columns of the mouse isocortex in the Allen Mouse Brain Common Coordinate Framework. The Allen Mouse Brain Atlas (and particularly its Common Coordinate Framework) has been key to advances in computational neuroanatomy in the adult mouse. However, this atlas does not contain detailed annotations of the barrel cortex, which is the dominant topographically represented whisker-related area of the primary somatosensory cortex. The barrel cortex is a highly relevant system to study as mice are nocturnal, tunnel-dwelling animals that largely rely on their whiskers to survive. These annotations allow researchers to much more precisely localise features of interest within specific barrel columns vs. other barrels, within barrels vs. septa, for example, rather than the barrel field as a whole.
New brainmapper napari widget released
- 31 July 2024
One common use of BrainGlobe tools is to analyse the distribution of cells in a whole brain image. This process
involves first detecting cells using cellfinder and then registering (aligning) the
data to a BrainGlobe atlas using brainreg. The detected cell positions must then be
transformed from the coordinate space of the raw data to the coordinate space of the atlas for analysis.
BrainGlobe version 1.1.0 is released!
- 16 May 2024
A new version of the BrainGlobe metapackage has been released following updates to lots of BrainGlobe tools (details below).